Cardiac Output Leg Muscle Activity

Cardiac Output Leg Muscle Activity

Cardiac Output Leg Muscle Activity

Fingers of the cytoplasmic membrane can be rapidly projected by the cytoskeleton and just as rapidly contracted. The membrane is pushed out by the addition of protein subunits to rigid actin microfilaments. Motor proteins, such as myosin, can attach to different actin microfilaments and force them to slide past each other using ATP. This movement causes the furrowing of membrane in cell division and is highly magnified in muscle contraction.

Dynamic Instability and Actin Polymerization

ATP binds to actin proteins and facilitates polymerization at the plus end of actin microfilaments. As part of the filament, the ATP spontaneously hydrolyzes to ADP. Thus, as long as the actin microfilaments continue to grow, there are freshly added, ATP-containing actin proteins at the growing end. If growth slows, then the terminal actin proteins end up with ADP and they spontaneously depolymerize. This is the same type of dynamic instability observed in the much larger microtubules of the cytoskeleton.


  • Cardiac Output Leg Muscle Activity

    Cardiac Output Leg Muscle Activity

    Cardiac Output Leg Muscle Activity

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